GENETIC CONTRIBUTION AND ASSOCIATED PATHOPHYSIOLOGY IN END-STAGE RENAL DISEASE



Seryl-tRNA Synthetases in Translation and Beyond

For a long time seryl-tRNA synthetases (SerRSs) stood as an archetypal, canonical aminoacyl-tRNA synthetases (aaRS), exhibiting only basic tRNA aminoacylation activity and with no moonlighting functions beyond protein biosynthesis.The picture has changed substantially in recent years after the discovery that SerRSs play an important role in antibio

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New light in flavin autofluorescence

Concealer Our attention was captured by the interesting debate on the identification of lipofuscins, lipofuscin-like lipopigments, or flavins as the responsible for intracellular autofluorescence (AF) detected in epithelial cancer stem cells when exciting at 480-490 nm.Evidence was provided leading to ascribe AF emission to flavins accumulating in

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